Fluorescence

Non-Telecentric 2P microscopy for 3D random access mesoscale imaging (nTCscope)

Ultra-low-cost, easily implemented and flexible two-photon scanning microscopy modification offering a several-fold expanded three-dimensional field of view that also maintains single-cell resolution. Application of our system for imaging neuronal activity has been demonstrated on mice, zebrafish and fruit flies

An open-source experimental framework for automation of high-throughput cell biology experiments

Modern Biology methods require a large number of high quality experiments to be conducted, which requires a high degree of automation. Our solution is an open-source hardware that allows for automatic high-throughput generation of large amounts of cell biology data.

WholeBrain

WholeBrain is a software to create anatomical maps. With a code base in C/C++ with wrappers to R and JavaScript/WASM. The purpose of WholeBrain is to provide a user-friendly and efficient way for scientist with minimal knowledge of computers to create anatomical maps and integrate this information with behavioral and physiological data for sharing on the web.

pyPhotometry

pyPhotometry is system of open source, Python based, hardware and software for neuroscience fiber photometry data acquisition, consisting of an acquisition board and graphical user interface. pyPhotometry supports data aquisition from two analog and two digital inputs, and control of two LEDs via built in LED drivers with an adjustable 0-100mA output.

cellfinder

cellfinder is software from the Margrie Lab at the Sainsbury Wellcome Centre for automated 3D cell detection and registration of whole-brain images (e.g. serial two-photon or lightsheet imaging). It’s a work in progress, but cellfinder can: