The home cage automated skilled reaching apparatus HASRA individualized training of group housed mice in a single pellet reaching task
We developed an automated apparatus and single pellet reach training paradigm for group housed mice within the home cage. This task allows individualized training progression and handedness of presentation for each mouse, minimizes stress induced by experimenter interaction, and enables experiments and data collection on a massive scale, previously impossible due to the demands of one-on-one behavioral testing. We demonstrate an optimized set of task parameters and the utility of this apparatus for assessing lesion-induced motor impairments. Herein, we provide an open-source, scalable, platform for training and assessing skilled reaching in mice with minimal need for experimenter handling that is equivalent to gold-standard, manual single pellet training paradigms.
Gilles Salameh; Matthew S. Jeffers; Junzheng Wu; Julian Pitney; Gergely Silasi
This post was automatically generated by Greg Silasi